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A Iist of mutagenic chemicals


A list of mutagenic chemicals

  When 346 chemicals, of which significant mutagenicity has been established, of all chemicals reported about under the provisions of Article 57-3 of the Industrial Safety and Health Law and other 129 chemicals that the Government has chosen and tested to see if they were mutagenic are produced or handled, employers shall take such measures as chemical exposure-preventive measures, the measurement of working environment, occupational health education, the labeling and issue of material safety data sheets (MSDS) and the keeping of records in accordance with the Guidelines for the Prevention of Health Disorders from Carcinogenic Chemicals given in the Labour Standards Bureau Notification No. 312 dated May 17, 1993.
  Subject chemicals are as follows.


a. Reported chemicals

No.             Chemical name
1 Reaction product of 2-hydroxypropyl acrylate
and ethyleneimine
2 1-Azabicyclo [2.2.2] octane-4-carbonitrile=1/2 sulfate
3 4' -(Azidosulfonyl) acetanilide
4 Reaction product of polycondensed adipic
acid and chlorine
5 Mixture of dimethyl N-[3-Acetylamino-4-(2-carbamoyl-4-nitropheny-
lazo) phenyl]-2, 2'-iminodiacetate, dimethyl N-[3-acetylamino-4-(2-
cyano-4-nitrophenylazo) phenyl]-2, 2' -iminodiacetate and dimethyl
N-[5-acetylamino-2-(2-cyano-4-nitrophenylazo) phenyl]-2, 2'-iminodiacetate
6 (7S, 9S)-9-Acetyl-9-amino-7-(3,4-di-O-acetyl-2-deoxy-β-D-
erythro-pentopyranose-1-yloxy)-6,11-dihydroxy-5,7,8,9,10,12-
hexahydro-5,12-naphthacenedione
7 (7S, 9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranose-
1-yloxy)-6,11-dihydroxy-5,7,8, 9,10,12-hexahydro-5,12-naphthacenedione hydrochloride
8 (7S, 9S)-9-Acetyl-9-amino-7-(2-deoxy-β-D-erythro-pentopyranose-
1-yloxy)-6,11-dihydroxy -5,7,8,9,10,12-hexahydro-5,12-
naphthacenedione
9 (7S, 9S)-9-Acetyl-9-amino-6,7,11-trihydroxy-5,7,8, 9,10,12 -
hexahydro-5,12-naphthacenedione
10 1-(Acetylamino)-4-bromoanthraquinone
11 2-Acetyloxyiminomethylthioxanthene-9-one
12 1-Acetyl-4-methylnaphthalene
13 4-Acetoxy-2-(1-chloroethylthio)-6, 7-difluoro-3-quinolinecarboxylate
ethyl
14 Mixture of 3-acetoxy-3-bromopropionic acid, 3-acetoxy-3-bromopropionate ethyl and 3-bromoacetoxibromopropionate ethyl
15 5-Acetonyl-2-methoxybenzene sulfonyl=chloride
16 N-[2-[N2-[5-(Azepan-1-ylmethyl)-2-thienylcarbonyloxy] amidino]
ethyl] phthalimide
17 2, 2'-Azobis [2(hydroxymethyl) propiononitrile]
18 N-(3-Anilino-2-chloro-2-propenylidene) aniline=hydrochloride salt
19 3-Amidinothio-2-chloro propionate methyl=hydrochloride salt
20 1-Aminoehtylidene aminoformate=4-nitrobenzyl
21 ρ-Nitrobenzyl-(6R, 7R)-7-Amino-3-[(2S)-2-oxolanyl]-8-oxo-5-thia-1-
azabicyclo[4. 2. 0]octa-2-ene-2-carboxylate hydrochloride
22 Tetrasodium 2- [6- [4- [4- [6-Amino-5-(2-carboxy-4-nitrophenylazo)- 1-hydroxy-3-
sulfo-2- naphthylazo]-3- methoxyphenyl]-2-methoxyphenylazo] -2anilino-5-hydroxy-7-sulfo-1-naphthylazo]-1, 4-benzenesulfonate
23 Trisodium 3-[4-[4-[6-Amino-5-(2-carboxy-4-nitrophenylazo)-1-hydroxy-3-sulfo-2-
naphthylazo]-3-methoxyphenyl]-2-methoxyphenylazo]-4-hydroxy-5-
(ρ-methylphenylsulfonylamino)-2 , 7-naphthalenedisulfonate
24 Sodium 7-Amino-8-(2-carboxy-4-nitrophenylazo)-4-hydroxy-2-naphthalenesulfonate
25 2-Amino-6-chloro-3-nitropyridine
26 2-Amino-5-(2-chloro-4-nitrophenylazo)-4-methyl-3-thiophenecarbonitrile
27 2-Amino-2'-chloro-5-nitrobenzophenone
28 (6R, 7R)-7-Amino-3-chloromethyl-8-oxo-5-thia-1-azabicyclo [4.2.0] octa-
2-en-2-carboxylate-4-methoxybenzyl
29 (2R)-1-(6-Amino-2,3-difulorophenoxy)-2-propanol
30 2-Amino-3,5-dibromothiobenzamide
31 4-(4-Amino-2,5-dimethoxyphenylazo) benzoate hydrochloride
32 (2Z)-2-(5-Amino-1, 2, 4-thiadiazole-3-il)-2-(methoxyimino) acetyl=
chloride
33 Pivaloyloxymethyl (6R, 7R)-7-[(Z)-2-(2-Aminothiazole-4-il)-2-methoxyiminoacetamide]-
3-[(5-methyl-2H-tetrazole-2-il) methyl]-8-oxo-5-thia-1-azabicyclo [4.2.0]
octa-3-en-3-2-carboxylate
34 (7S,9S)-9-Amino-6, 7, 11-trihydroxy-9-(2, 5, 5-trimethyl-1, 3-
dioxane-2-yl-)5, 7, 8, 9, 10, 12-hexahydro-5, 12-naphthacenedione
hydrochloride
35 5-Amino-2, 4, 6-triiodoisophthalic acid=dichloride
36 1-Amino-4-nitroanthraquinone-2-carboxylate cyclohexyl
37 6-Amino-5-(2-hydroxy-4-nitrophenylazo)-N-methyl-2-naphtalenesulfonamide
38 2-(4-Aminophenylsulfonile)-5-nitrobenzenesulfonamide
39 N'-(4-Aminophenyl)-2-(4-tert-pentylphenoxy) acetohydrazide
40 6-Amino-7-fluoro-3, 4-dihydro-2H-1, 4-benzooxiadine-3-one
41 Sodium 1-Amino-4-(3-propionylaminoanilino)-2-anthraquinone sulfonide
42 3-Amino-4'-bromobiphenyl-4-ol
43 5' -Amino-2' -methoxy-4, 4-dimethyl-3-oxopentaneanilide=sulfate
44 N-Arylaniline
45 2-Chloro-2-propenyl isothiocyanate
46 7-(1-Imidazolyl)-6-nitro-2,3-dioxo-1, 2, 3, 4-tetrahydro-1-quinoxalinate ethyl
47 N-(2-Indanylidene) aniline
48 Ethanesulfonyl chloride
49 N-Ethylideneethylenediamine
50 2-Ethylacrylaldehyde
51 1-Ethyl-5-isopropylazulene
52 3-Ethyl-7-isopropyl-1-azulene carboxylate methyl
53 3-Ethyl-3-(2, 3-epoxipropoxymethyl) oxcetane
54 By-product from synthesis of 5-ethyl-2, 3-pyridinecarboxylic acid by
oxidation of 3-ethylquinoline
55 5'-[N-Ethyl-N-(2-maleimideethyl) amino-2'-(4-nitrophenylazo) acetanilide
56 N-[1-(Ethoxycarbonyl)-3-oxo-3- phenylpropyl]-alanine
57 N2-[(S)-1-Ethoxycarbonyl-3-oxo-3-phenylpropyl]-N2-trifluoroacetyl-L-lysine
58 catena-m-[2-Ethoxycarbonyl-3-(4,6-dibromo-3-fluoro-2-methylphenyl)
-3-oxydoacrylate (2-)-0, 0', 0", ] magnesium (ll)
59 1,2-Epoxy-3-(4-vinylbenzyloxy) propane
60 Mixture of 1, 2-epoxy-3-(3-vinylbenzyloxy) propane and 1,2-
epoxy-3-(4-vinylbenzyloxy) propane
61 Reaction product of 2, 3-epoxypropan-1-ol
and tetramethyl orthosilicate polycondensation product
62 Mixture of 3-(2, 3-epoxypropyloxy)-1, 2-epoxypropane, 3-[bis (2-
methoxy-1-methylethoxymethyl) methoxy]-1, 2-epoxypropane, 1, 3-
bis (2-methoxy-1-methylethoxy)-2-propanol and 3-(2-methoxy-1-
methylethoxy)- 1,2-epoxypropane
63 6-(2, 3-Epoxypropoxy)-1,2-dihydroquinoline-2-one
64 5-(2, 3-Epoxypropoxy)-3, 4-dihydroquinoline-2 (1H)-one
65 4-(2, 3-Epoxypropoxy)-2-methyl-1,2-dihydroisoquinoline-1-one
66 Distillation residue in the production process of 3-chlorocyclohexene and trans-1, 2-dichlorohexane from chloride, cyclohexene, 2, 6-
di-tert-butyl-4-methylphenol
67 3-(2' -Oxocyclohexyl) propanal
68 N-[(6R)-5-Oxo-2-(2-thienyl) perhydro-1, 4-thiazepin-6-il] carbamate=tert-butyl
69 4-Octyloxynitrobenzene
70 10-(3-Chloro-1-azabicyclo [2.2.2] octa-3-ylmethyl) phenothiazine
71 2-Chloroisonicotinonitrile
72 2-Chloro-3-isobuthoxy-1-cyclobuthanone
73 ρ-(2-Chloroethyl) anisole
74 2-Chloroethylsulfonylbenzene
75 1-(2-Choloroethyl)-4-piperidinecarbonitrile=hydrochloride salt
76 4-Chloro-3-ethyl-1-methyl-5-pyrazolcarbonyl=chloride
77 Chemical gained from polycondensation of 1-chloro-2, 3-epoxypropane2. 7-naphthalenediol formaldehyde
78 Chemical gained from polycondensation of 1-chloro-2, 3-epoxypropane2, 2-bis (bromomethyl)-1,3-propanediol
79 Reaction product of 3-chloro-1, 2-epoxypropane-4, 4' -(propane-2, 2-diyl)diphenol polycondensation
product and {poly(oxyethylene) poly [oxy (2-hydroxytrimethylene)]}
80 Chloroformic acid= 1-chloroethyl
81 2-(2-Chloro-5-chloroacetyl-4-fulorophenoxy)-N-methylacetamide
82 β-Chloro-N-(2-chloroethyl)-N-methylphenethylamine
83 β-Chloro-N-(2-chloroethyl)-N-methylphenethylamine hydrochloride
84 2-Chloro-2-(2-chlorophenyl) ethanol
85 1-Chloro-3-(4-chlorophenyl) hydraxono-2-propanon
86 2-Chloro-5-chloromethyl-1,3-thiazole
87 4-Chloro-1, 3-dioxolane-2-one
88 2-Chlorocyclohexa-1-ene-1,3-dicarbaldehyde
89 4-Chloro-1,2-dihydro-3H-2a-azaacenaphthylene-3-one
90 4-Chloro-2,3-dimethylpyridine=N-oxide
91 2-Chloro-5-(trichloromethyl) pyridine
92 Chlorotris (dimethylamino) phosphonium chloride
93 N-(2-Chloro-3-nitro-6-pyridyl) actamide
94 4-(2-Chloro-4-nitrophenylazo)-N-(2-cyanoethyl)-N- phenethylaniline
95 5-Chloro-2-nitrobenzenethiol
96 6-(3-Chloro-2-hydorxypropoxy)-1,2-dihydroquinoline-2-one
97 Methyl 6-chloro-4-hydroxy-1,1-dioxo-1λ 6-2H-thieno [2, 3-e]
[1, 2] thiazine-3-carboxylate
98 Mixture of (2R)-1-chloro-3-(7-fluoro-4-indanyloxy)-2-propanol and
(2S)-1, 2-epoxy-3-(7-fluoro-4-iondanyloxy) propane
99 3-Chloro-4-fluoronitrobenzene
100 2-[2-Chloro-4-fluoro-5-(5-hidroxy-1-methyl-3- pyrasolyl)phenoxy]-N-
methylacetamide
101 2-Chloro-4' -fluorobenzophenone
102 1-(2-Chlorobenzyl)-3-(α , α-dimethylbenzyl) urea
103 1-Chloro-2-pentyne
104 2-Chloroformyl-1-pyrrolidine carboxyfate benzyl
105 Chloromethanesulfonyl chloride
106 m-Chloromethylanisole
107 3-Chloro-N-methylaniline
108 4-Chloromethyl-2-isopropylthiazole
109 1-(Chloromethyl) thio-4-nitrobenzene
110 2- (4-Chloromethyl-4-hydroxy-2-thiazoline-2-il) guanidine=hydrochlo-
ride salt
111 2-(4-Chloromethylphenyl) propionate ethyl
112 Methyl 2-(2-chloromethylphenyl) acetate
113 2-[o-(or m- or ρ-)(Chloromethyl) phenyl] propionate methyl (mixture)
114 Mixture of [3-(chloromethyl) phenethyl] trimethoxysilane and [4-
(chloromethyl) phenethyl]trimethoxysilane
115 (2S)-3-Chloro-2-methylpropionyl=chloride
116 (2S)-3-Chloro-2-methylacetic acid
117 4-Chloromethyl benzyl alcohol
118 1-Chloromethyl-1H-benzotriazole-5(or 6)-carboxylate methyl (mixture)
119 Methyl 5-chloromethyl-2-methoxybenzoate
120 (Chloromethoxy) ethane
121 (Z)-4-Chloro-2-(methoxycarbonylmethoxyimino)-3-oxobutyric acid
122 2, 3-Epoxypropyl acetate
123 2-(2, 3-Epoxypropyl)-6-methoxyphenyl acetate
124 1-Chloroformyl- 1-methylethyl acetate
125 Mixture of 2-hydroxy-3-butenyl acetate and 1-hydroxymethyl-2-
propenyl acetate
126 Acetic acid=1-bromoformyl-1-methylethyl
127 Nitrogen trifluoride
128 5' -[N-(2-Cyanoethyl)-N-ethylamino]-4' -methoxy-2' -(5-nitro-2,1-benzoisothiazole-3-ilazo) acetanilide
129 N2-(3-Cyano-5-nitro-2-thienyl)- N1, N1-dimethylformamidine
130 Sodium 3-[N-[8-(2-Cyano-4-nitrophneylazo)-5-hydroxy-6- propionylamino-1-
naphthyl] sulfamoyl] benzene sulfonate
131 4-[3-5-Cyano-4-nitro-2-methoxyphenoxy] propyl]
morpholine=mono-sulfate
132 3, 3'-Diaminobenzophenon
133 4, 6-Diaminoresorcinol=dichloride
134 By-product from the synthesis of 1-[2-(2-chlorobenzoil)-4-nitrophenyl]-2-(diethylaminomethyl) imidazole with 2-[N, N-dimethylami-
nomethyl] imidazole and 2, 2' -dichloro-5-nitrobenzophenon (extracts in water phase)
135 Product of the de-hydrochroine response of 2-(N, N-dimethylaminomethyl) imidazole and 2, 2' -dichloro-5-nitrobenzophenon (extracts in toluene phase)
136 5-Diethylamino-5' -nitro-2, 2' -azodiphenol
137 N-(4-Diethylaminobenzylidene) aniline=N-oxide
138 (5R)-5-[(2R)-1, 4-Dioxaspiro [4, 5] decane-2-il]-3, 4-dihydroxy-2, 5-
dihydro-furan-2-one
139 1, 3, 2-Dioxathiolane=2-oxide
140 [SP-4-2]-[(1R, 2R)-Cyclohexane-1, 2-diamine-κ2 N, N'][oxalato (2-)-
κ2O, O'] platinum (ll)
141 1-Cyclohexyl -1-ethanone=3-fluoro-ρ-tolylhydrazone
142 2' , 4' -Dichloroacetophenone
143 α, α-Dichloro-ρ-xylene
144 Mixture of 1, 3-dichloro-5-(chloromethylthio) benzene and 1,3-
Dichloro-5-(dichloromethylthio) benzene
145 4, 5-Dichloro-1, 3-dioxolane-2-one
146 [SP-4-2]-Dichloro [(1R, 2R)-cyclohexane-1, 2-diamine- κ2 N, N'] plati-
num (ll)
147 Reaction product of dichlorodi (cyclopenta-2, 4-
diene-1-yl) titanium (lV) and 2-furylmethanol
148 1, 4-Dichloro-2-trichlorosilyl-2-butene
149 2, 4-Dichloro-5-trifluoromethylnitrobenzene
150 2, 2'-Dichloro-5-nitrobenzophenone
151 2, 2-Dichloro-1-nitroethylene
152 2, 6-Dichloro-3-nitropryridine
153 2, 3-Dichloropyrazine
154 2, 4-Dichloro-3-fluoronitrobenzene
155 2, 6-Dichloro-1-fluoropyridinium=tetrafluorphorate
156 α , α -Dichloro-4-fluorotoluene
157 2, 3-Dichloro propionate methyl
158 2, 3-Dichloropropene
159 2, 6-Dichloro-3-perchloromethyltoluene
160 4, 5-Dichloro-2-perchloromethyltoluene
161 2, 2 (or 4)-Dichloro-3-pentanone (mixture)
162 Mixture of (dichlorophosphino) biphenyl (mixture) and 2 (or 3
or 4), 2' (or 3' or 4')-bis (dichlorophosphino) biphenyl (mixture)
163 Dichloromethylphosphine
164 2, 2-Dichloro-3-methylbutylaldehyde
165 2, 3-Dichloro-2-methylpropanal
166 3, 5-Dichloro-4-methoxynitrobenzene
167 4-(2,6-Dicyano-4-nitrophenylazo)-3-methyl-N, N-diethylaniline
168 2', 3'-Dideoxyadenosine
169 2', 3'-Dideoxyinosine
170 3, 5-Dinitro benzoate=2-(methacryloiloxy) ethyl
171 2, 2' -Dihydroxy-1, 1 '-binabutyl
172 N, N'-Di-tert-butylethylenediimine
173 3,4-Difluoro-o-anisidine
174 1, 5-Difluoro-2, 4-dinitrobenzene
175 3, 4-Difluoronitrobenzene
176 1, 2-Difluoro-3-methoxy-4-nitrobenzene
177 2'-(2,6-Dibromo-4-nitrophenylazo)-5'-diethylaminoacetanilide
178 1, 4-Dibromo-2-nitrobenzene
179 1, 4-Dibromo-2-butene
180 3-(4, 6-Dibromo-3-fluoro-2-methylphenyl)-3-oxopropionate ethyl
181 N-(2, 3-Dibromopropyl)-N, N-diformylhydrazine
182 Dibenzyl= phenylsulfonium=hexafluoroantimonate
183 Reaction product of 2H-dibenzo [c, e] [1, 2]
oxaphosphinine=2-oxide, 1, 4-naphthoquinone and phenol-formaldehyde polycondensation product and 1-chloro-2, 3-epoxypropane
184 3-[1-(2-Dimethylaminoethyl)-1H-1, 2, 3, 4-tetrasol-5-ilthiomethyl]-7-
(4-nitrophenylthioamino)-8-oxo-5-thia-1-azabicylo-[4,2,0] octa-2-en-
2-carboxylic acid
185 N, N-Dimethyl-N-[3-imino-2, 8-dimethyl] phenoxadine-7-il] amine=
hydrochloride
186 N, N-Dimethyl-N' -(4-nitrosophenyl)-ρ-phenylenediamine
187 2, 3-Dimethyl-4-nitropyridine=1-oxyde
188 3, 5-Dimethyl-4-nitropyridine=1-oxyde
189 2, 6-Dimethylphenylhydrazine=hydrochloride
190 6-(1, 3-Dimethylbutylideneamino)-7-fuloro-3,4-dihydro-2H-1,4-
benzo-oxazine-3-one
191 6-(1, 3-Dimethylbutylideneamino)-7-fluoro-4-(2-propynyl)-3, 4-dihydro-,
2H-1,4- benzooxazine-3-one
192 3, 3-Dimethyl-1-butyne
193 2, 4-Dimethyl benzenesulfonyl=chloride
194 3, 4-Dimethoxybenzoil=chloride
195 Residue gained from the depressurized distillation of coal-liquefied
crude oil
196 2-Chloro-4-fuloro-5-nitrophenyl=ethyl carbonate
197 Cyclohexl=1-iodineethyl carbonate
198 2-Chloro-2-propenyl thiocyanate
199 2, 2, 6, 6 -Tetrachlorocyclohexanon
200 2, 2',4, 4' -Tetrachlorobenzophenon
201 2, 3, 6, 7-Tetrahydro-1H,5H-benzo [ij] quinolizine
202 2, 3, 6, 7-Tetrahydro-1H,5H-benzo [ij] quinolizine=monohydrochloride
203 2, 2, 3, 3-Tetrafluorooxetane
204 Bis (2,3-epoxypropyl) terephthalate
205 (R)-2-Tosyloxyl propionate methyl
206 Trioctyle-tin (lV) azide
207 Trichloro zincic acid (ll)-5-diisopropylamino-2-(4-dimethylaminophenylazo)-3-methyl-1, 3, 4-thiadiazolium
208 2, 4, 4-Trichloro-3-isobutoxy-2-cyclobutene-1-one
209 2, 2, 6-Trichloro-6-(1-chloroisobutyl) cyclohexanon
210 2, 3, 4-Trichloro-1,5-dinitrobenzene
211 1, 1, 1-Trichloro-2-nitroethane
212 2-Trichloromethyl-5-(4-hydroxystyryl)-1,3, 4-oxadiazole
213 Tris [3-(2-methylaziridine-1-il) propionic acid]=propylidine trimethyl
214 2, 3, 4-Trifluoronitrobenzene
215 Trifluoromethanesulfonyl=fluolide
216 2, 2, 2-Trifluoroethyl trifluoromethanesulfonate
217 Trifluoroiodomethane
218 Mixture of 2, 2, 4-trimethyladipoyl=dichloride and 2, 4, 4-trimethyladipoyl=dichloride
219 N-[1-[3-[(2R, 3S)-3-[(R)-1-(trimethylsililoxy) ethyl]-4-oxo-2-azetidinylmethylcarbonylthio]=-1-pyrrolidinil] ethylidene] carbamate ρ-nitrobenzyl
220 3' 4' 5'-Trimethoxycinnamoyl=chloride
221 ρ-Toluenesulfonyl azide
222 ρ-Toluenesulfonate=ethylpropyl
223 ρ-Toluenesulfonate=2, 3-epoxypropyl
224 ρ-Toluenethiosulfonate=S-chloromethyl
225 1-Naphthalenediazonium=tetrafluoro borate
226 Prcduct from the reaction of sulfur dichloride and 2, 2, bis (4-
hydroxyphenyl)-1, 1, 1 , 3, 3, 3-hexafluoropropane and benzene
227 4-Nitrobenzoate=[4-(2, 2-dicyanovynil) phenyl]
228 4- Nitro- 1 H-indasol
229 5-Nitroindole
230 6-Nitroindole
231 Ethyl 5-nitro-2-indolcarboxinate
232 5-Nitroindoline
233 6-Nitroindoline
234 2-Nitro-5-(1-piperazinil) benzaldehyde=hydrochloride
235 4-(4-Nitrophenyleazo)-N-(2-cyanoethyl)-N-(2-acetoxyethyl) aniline
236 2-Nitrophenylthiobenzene
237 1-(4-Nitrophenoxy)-2-propanon
238 3-Nitrophthalonitrile
239 (5R, 6S)-3-[(S)-1-[N-(ρ-Nitrobenzyloxycarbonyl) acetimidoil]-3-pyrrolidinylthio]-7-oxo-6-[(R)-1-(trimethylsilyloxy) ethyl]-1-azabicyclo [3.2.0]
hepta-2-en-2-carboxyate=ρ-nitrobenzyl
240 2-Nitrobenzene sulfonic acid=4-chlorobutyl
241 5'-[Bis (2-acetoxyethyl) amino]-2' -(2-chloro-4-nitrophenylazo) acetanilide
242 Bis (2, 3-epithiopropyl) sulfide
243 N, N-Bis (2, 3-epoxypropyl)-4-(2, 3-epoxypropoxy) aniline
244 1,3-Bis (2, 3-epoxypropoxy)-2-(2, 3-epoxypropyl) benzene
245 Bis (2,3-epoxypropyl) disulfide
246 Bis (2,3-epoxypropoxy) sulfide
247 Residue in the distillation of bis (2, 3-epoxypropyl) sulfide
248 1,6-Bis (2, 3-epoxypropoxy) naphthalene
249 4,4'-Bis (2, 3-epoxypropxy) biphenyl
250 1,1'-Bis [ρ-(2,3-epoxypropoxy) phenyl] ethane
251 Bis (2-chloroethylsulfonyl) methane
252 N, N'-Bis (2-chloroethyl) benzhydrylamine hydrochloride
253 1,1 '-Bis [ρ-(3-chloro-2-hydroxypropoxy) phenyl] ethane
254 2, 5-Bis (chloromethyl)-1,4-dithian
255 5, 8-Bis [2-(2-hydroxyethylamino) ethylamino]-1,4-anthraquinonediol
=dihydrochloride
256 Bis [2-(2-hydroxy-3, 5-dynitrophenylazo)-3-sulfo-6 (or 7)-acetylamino-
1-naphtholate (0, 0')(2-)] hydro chromate (lll)=potassium (or sodium)
(mixture)
257 Mixture of sodium salt and ammonium salt of bis [2-(2-hidroxy-
5-nitrophenylazo)-3-sulfo-6 (3-phosphonate anilino)-1-naphtolate-
(0. 0')(4-)] cobalt (Ill)
258 1, 3-Bis (hydroxymethyl)-1 -[1,3,-bis (hydroxymethyl)-2,5-dioxoimida
zolidine-4-il] urea
259 Bis [2-(5-hydroxy-3-methyl-1-phenyl-4-pyrazolylazo)-5-nitrophenolato-
(0, 0')(2-)]cobalt (lll) hydrate
260 Bis (vinylsulfonyl) methane
261 1,3-Bis (2-methyl-1-aziridinylcarbonyl) benzene
262 4-Hydroxy benzoic acidformaldehydesulfic acid=hydrogen=4-polycondensed anilinobenzenediazonium
263 3-Hydroxy-1,1-dimethylbutylhydroperoxyde
264 3-Hydroxy-2-naphthohydroxamic acid
265 2'-Hydroxy-4'-nitro-1,1,2,2 ,3,3, 3 -heptafluorobutylanilide
266 1-Hydroxy-N-(2-hidryoxypropyl)-4-[2-(4-nitrophenoxy) ethoxy]-2 -napthoamide
267 3-Hydroxymethyl-1 -(2-propynyl)-2, 4-imida zolidinethione
268 [2-[5-Hydroxy-3-methyl-1-(p-tolyl)-4- pyrazolylylazo]-6-nitro-4-sulfophenolato-(0, 0')(2-)][2-(5-hydroxy-3-methyl-4-pylazolylazo)-5-
nitrophenolato-(0, 0')(2-) chrome (lll) hydrate
269 5-Hydroperoxy-5-methyl-1,2-dioxolan-3-one
270 Vinylsulfonylbenzene
271 lodomethyl pivalate
272 Sodium 2-(4-biphenylyl)-2-chloroacetate
273 3, 3', 4, 4'-Biphenyltetraamine
274 N-(2-Pyridil dithiocarbamate methyl ester)
275 3-Pyridylhydrazine
276 1 -Pyrencarbardehyde
277 Reaction product of thiourea and
glycidyletherification product of phenol-formaldehyde polycondensation product
278 N1-[3-(2-Phenoxyethoxy)-1H-pyrazol-5-il]-3-nitrobenzamidine
279 Reside in the distillation in the production of 2-ethylacrylaldehyde
from butylaldehyde and formaldehyde
280 2-tert-Butyl-5-chloro-6-nitrobenzooxazole
281 2-(6-tert-Butyl-7, 7-dichloro-7H-pyrazolo [3,2-c] [1 ,2,4] triazole-3-
yl)-2-methylpropane-1-ol
282 (4R)-4-[2R, 3S]-3-(1R)-1-(tert-Butyldimethylsilyloxy) ethyl-4-oxo-2-azetidinyl]-2-diazo-3-oxovalerate=ρ-nitrolbenzyl
283 2-tert-Butyl-6-nitro-5-[ρ-(1,1, 3,3-tetramethylbutyl) phenoxy]
benzo-oxazole
284 5-tert-Butyl-2-(4-nitrophenyl)-1 H-prazolo [1,5, -b][1,2, 4] triazole
285 4-tert-butylpyrocatechol1-chloro-2, 3-epoxypropane
polycondensation product
286 N-(tert-Butoxycarbonyl)-S-[2-nitro-1-(2-thienyl)ethyl]-L-cysteine
287 2-Furancarbonyl=chloride
288 2-(2-Fluoroacetylamino)-5-nitrobenonic acid
289 2-(5-Fluoro-2, 4-dinitrophenoxy) acetate butyl
290 2'-Fluoro-5'-nitroacetophenon
291 Fluoromethane
292 1-(2-Fluoro-5-mnethylsulfonylamino β-oxophenetil) 3, 5, 7-triaza-1 -
azoniatricyclo [3. 3.1.13, 7] decane=bromide
293 3-Fluoro-4-methylphenylhydrazine
294 2, 3-Epoxypropyl propionate
295 3-Bromo-2-methyl-propionic acid
296 2-(2-Bromoethyl)-1 , 3-dioxiane
297 2-(2-Bromoethyl)-1 , 3-dioxolane
298 4-Bromo-3-oxobutyloanilide
299 2'-(2-Bromo-4, 6-dinitrophenylazo)-5'-[N-(2-cyanoethyl)-N-ethylamino)
-4'-methoxyacetoaniride
300 2'-(2-Bromo-4,6-dinitrophenylazo)-5'-(2-cyanoethylamino)-4'-methoxyacetanilide
301 2-Bromo-1,1-difluoroethene
302 4-Bromo-1-tosyl-1-benzoazepane-5-one
303 2 Bromo-3, 3, 3-trifluoro-1-propene
304 4-Bromo-2-nitrophenol
305 4-Bromo-1-butene
306 2-Bromo-4'-(methylsulfonyl) acetophenone
307 1-Bromomethyl-3-nitrobenzene
308 4'-Bromomethyl-2-biphenylcarbonitrile
309 tert- Butyl 4' -bromomethyl-2-biphenylcarboxylate
310 (E)-3-[ρ-(Bromomethyl) phenyl]acrylic acid
311 (E)-3-[ρ-(Bromomethyl) phenyl]acrylate ethyl
312 2-(4-Bromomethylphenyl) pyridine=benzene sulfonate
313 1-Bromo-2-methyl-2-propene
314 4-Bromo-2-methoxyimino-3-oxobutylyl=chloride
315 Mixture of perhydroisoquinoline magnesium (ll) chloride and bis
(perhydroisoquinoline) magnesium (ll)
316 Perfluoropropoxy-1 ,1 , 2-trifluoroethylene
317 4'-Benzyloxy-3'-nitroacetophenone
318 4'-Benzyloxy-3'-nitro-2-bromoacetophenone
319 1-Benzyl-2-(chloromethyl) imidazole=hydrochloride
320 Benzaldehyde=4-methylphenylhydrazone
321 S-Trichloromethyl benzenthiosulfonate
322 1,3,5-Benzenetriamine
323 3-Benzoil acrylate ethyl
324 N-[β-(Benzo [b] furan-2-il) acryloyl]-N'-trichloroacetohydrazine
325 2, 2',3, 4, 4'-Pentahydroxybenzophenone
326 Pentafluoroiodoethane
327 Pentafluoroethanesulfonyl fluoride
328 1-Formyl-2-(4-aminophenyl) hydrazine
329 N-[4-(2-Formylhydrazino) phenyl] carbamate phenyl
330 Malonate=4-nitrobenzyl
331 (3R)-Mesyloxy-1-[N-(4-nitrobenzyloxycarbonyl) acetoimidoil] pyrrolidine
332 9-Anthrylmethyl methacrylate
333 Methacrylate= phthalimidemethyl
334 Methane sulfonate=(R)-2-methyl-4-oxo-3-(2-propynyl)-2-cyclopen-tenyl
335 Methane sulfonate methyl
336 9-Methylcarbazole
337 4-Methyl-1 -(2, 4-dinitrophenyl) pyridinium=chloride
338 3-(N-Methyl-N-vinyldimethylsilylamino) aniline=chloride
339 N-(2-Methyl-3-phenylimino-1-propenyl) aniline=hydrochloride
340 3-Methyl-2-butanone=3-pyridylhydrazone
341 1 -Methoxy-3, 5-dimethyl-4-nitropyridinium=methylsulfate
342 2-[2-Methoxy-4-[3-(2-tricloroacetylhydrazino)-3-oxo-1-propenyl]
phenoxy] acetate methyl
343 4-Methoxy-3-nitrobiphenyl
344 4-Methoxy-3-biphenylamine=hydrochloride
345 3-(2-Methoxy-1-methylethoxy)-1,2-epoxypropane
346 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile


b. Existing chemicals

No Chemical name
1 2-Hydroxyethyl acrylate
2 Acryionitrile
3 1-Acetyl-5-nitroindoline
4 Acetaldehyde
5 2-Aminoanthraquinone
6 2-Amino-5-nitrobenzonitrile (2-cyano-4-nitroaniline)
7 7-Amino-4-hidroxy-2-naphthalenesulfonic acid (J acid)
8 3' -Amino-4' -methoxyacetanilide (5-acetylamino-2-methoxyaniline)
9 1-Aryloxy-2, 3-epoxypropane (allylglycidylether)
10 Allylchloride (3-chloro-1 -propene)
11 Allylbromide (3-bromo-1 -propene)
12 9-Ethylcarbazole-3-carbardehide
13 1, 2-Epoxy-3-phenoxypropane (phenylglycidylether)
14 2, 3-Epoxy-1-propanol
15 1, 2-Epoxypropane (propyleneoxide)
16 Ethyl chloride
17 Methyl chloride
18 Methylene chloride (dichloromethane)
19 3-Oxomethyl butyrate
20 8-Quinolinol (8-hydroxyquinoline)
21 Quinoline
22 Glyoxal (ethanedial)
23 Glutaraldehyde
24 Crotonaldehyde (2-butenal)
25 Chloroacetaldehyde
26 1 -Chloro-2, 3-epoxypropane (epichlorohydrin)
27 2'-(4-Chloro-3-cyano-5-formyl-2-thienylazo)-5'-diethylaminoacetanilide
28 2'-(4-Chloro-3-cyano-5-formyl-2-tienylazo)-5'-diethylamino-2-methoxyacetanilide
29 1-Chloro-2, 4-dinitrobenzene
30 2-Chloro-4, 6-dinitroaniline
31 O, O '-Dimethyl chlorothiophosphonate
32 2-Chloro-4-nitroaniline
33 5-Chloro-2-nitroaniline (2-amino-4-chloro-1-nitrobenzene)
34 ρ-Chloronitrobenzene
35 2-Chloronitrobenzene
36 4-Chloro-1,3-phenylenediamine (2, 4-diaminochlorobenzene)              
37 4-Chloro-1,2-phenylenediamine (3, 4-diaminochlorobenzene)              
38 5-Chloro-1,3-phenyienediamine (3, 5-diaminochlorobenzene)              
39 3-Chloro-2-fluoronitrobenzene
40 3-Chloropropionic acid (β-chloropropionic acid)
41 3-Chloro-2-methyl-1-propene (Byname:methallychloride)
42 2-Chlorobutyric acid
43 Cobalt (ll) acetate tetrahydrate
44 3, 5-Diaminobenzoic acid
45 1, 4-Diaminoanthraquionone (1,4-diamino-9, 10-anthracenedione)        
46 4, 4'-Diaminodiphenylether (bis (4-aminophenyl) ether)
47 2, 4-Diaminotoluene (m-toluylenediamine)
48 3, 5-Dichloroaniline
49 1, 2-Dichloro-1-ethoxyethane (1,2-dichloroethylether)
50 Dichloroacetate methyl
51 4, α -Dichlorotoluene 4-chlorobenzyl chloride
52 1, 4-Dichloro-2-nitrobenzene
53 2, 4-Dichloro-1-nitrobenzene
54 1, 2-Dichloro-4-nitrobenzene
55 2, 3-Dichloro-1-propanol
56 1, 3-Dichloropropene
57 2-(4,α -Dichlorobenzyl) pyridine
58 2, 4-Dinitroaniline
59 Dinitrosopentamethylenetetramine (3, 7-dinitro-1,3, 5, 7-tetraazabicyclo [3.3.1] nonane)
60 2, 4-Dinitrotoluene
61 1, 5-Dinitronaphthalene
62 1, 8-Dinitronaphthalene
63 1, 4-Dihydroxyanthraquinone
64 Diphenylamine
65 N, N-Dipphenylnitrosoamine (N-nitrosodiphenylamine)
66 N, N'-Diphenyl-1,4-phenylenediamine
67 1, 2-Dibromoethane
68 1, 4-Dibromobutane
69 1, 3-Dibromopropane (trimethylene dibromide)
70 2, 3-Dibromo propyonic acid
71 Diborane
72 2, 4-Dimethylaniline (2, 4-xylidine)
73 N, N-Dimethylaniline
74 1, 1-Dimethylhydrazine
75 3, 3' -Dimethyl-4, 4' -biphenyleneisocyanate (O-tolidinediisocyanate)
76 Vinyl bromide
77 Methyl bromide
78 Silane
79 Styrene oxide (1,2-epoxy-1 -phenylethane)
80 1 , 3, 5, 7-Tetraazatricyclo [3.3.1.13,7] decane (Byname:urotropin, hexamethylenetetramine)
81 2, 3, 5, 6-Tetrachloro-1 ,4-benzoquinone (Chloranil)
82 Tetramethylthiuramdisulfide (bis (dimethylcarbamyl) disulfide)
83 2, 4, 6-Trichloro-1 ,3, 5-triazine (cyanurtrichloride)
84 1 , 2, 3-Trichloropropane
85 ρ-(Trichloromethyl) chlorobenzene (ρ-chlorobenzotrichloride)
86 1 , 3, 5-Tris (2, 3-epoxypropyl) hexahydro-1,3, 5-triazine-2,4, 6-trion
87 2, 4, 6-Trinitrophenol (picric acid)
88 2, 4, 6-Trimethylaniline
89 2, 6-Tolyenediisocyanate
90 ρ-Toluenesulfonohydrazide
91 o-Nitroaniline
92 m-Nitroaniline
93 4-Nitro-o-phenylenediaminehydrochloride
94 5' -[Bis (2-acetoxyethyl] amino]-2' -(2-bromo-4, 6-dinitrophenylazo)-
4'-methoxyacetanilide
95 5' -[N, N-Bis [2-(isobutoxycarbonyloxy)ethyl] amino]-4'-methoxy-2'-
(5-nitro-2-thiazolylazo) acetanilide
96 Bisphenol Type A epoxy resin intermediate
97 Hydrazine (hydrazine anhydride)
98 Phenylhydrazine
99 o-Phenylenediamine (o-diaminobenzene)
100 m-Phenylenediamine (m-diaminobenzene)
101 ρ- Phenylenefiam ine (ρ-diaminobenzene)
102 1, 3-Butadiene
103 Butyraldehyde
104 1 -Butoxy-2, 3-epoxypropane (butylglycidylether)
105 Propyne (methylacetylene)
106 Bromoacetylbromide
107 1 -Bromo-2-chloroethane
108 1 -Bromo-3-chloropropane
109 Bromochloromethane
110 Bromoacetic acid
111 2-Bromopropane
112 3-Bromopropionic acid (β-bromopropionic acid)
113 Ethyl 3-bromopropionate (β-ethylbromopropionate ethyl)
114 Benzylchloride (bezyl chloride)
115 Benzaldehyde
116 Benzo[f]quinoline
117 ρ-Benzoquinoneoxime
118 Poly (oxymethylene) (Also known as paraformaldehyde)
119 2-Methyl-4-nitroaniline
120 Methylhydrazine
121 Methylenebis (4-phenylisocynate) (4, 4'-diphenylmetanediisocyanate)
122 Intermediate of methylenebisphenol-type epoxy resin
123 o-Methoxyaniline (o-anisidine)
124 ρ-Methoxynitrobenzene (ρ-nitroanisole)
125 2-Methoxine-5-methylaniline
126 Methyl iodide
127 3-Iodopropionic acid (β -iodopropionic acid)
128 Diethyl sulfate
129 Dimethyl sulfate

Note 1: Those chemicals are ones that proved positive in a mutagenicity test that used microorganisms and a chromosomal aberration test that used mammalian cell culture.
Note 2: The chemical (No. 23, above) is described as having no evidence of carcinogenicity as a result of a rat and mouse test in a technical report of the National Toxicology Program (NTP) in the United States.
Note 3: Regarding the chemicals of above No. 18 and 34, health impairment prevention measures are to be taken in due consideration of their carcinogenicity, in accordance with the Guidelines for the Prevention of Dichloromethane-derived Health Impairment (Guidelines for the Prevention of Health Impairment, No. 12, dated January 21, 2002)and the Guidelines for the Prevention of Para-nitrochlorbenzene-derived Health Impairment (Guidelines for the Prevention of Health Impairment, No. 4, March 25, 1994) which are formulated based on the provisions of Article 28-3 of the Industrial Safety and Health Law (Law No. 57 of 1972).

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