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INDUSTRIAL HEALTH 1990,28,53-62
An Epidemiological Study on Cancer in Certified
Arsenic Poisoning Patients in Toroku
Toshihide TSUDA1), Tsuyoshi NAGIRA1), Makoto YAMAMOTO1)
and Yukinori KUME2)
1) Oita Kyouwa Hospital, Workers' Cooperation for Medical Care in Oita Prefecture,
953-1, Oaza Miyazaki, Oita city 870-11, Japan
2) Saiki Clinic, Workers' Cooperation for Medical Care in Oita Prefecture
14-21, Nakanoshima 1-chome, Saiki city 876, Japan
(Received September 6, 1989 and in revised form March 20, 1990)
Abstract: A mortality study has been made to assess the carcinogenic effect of arsenic exposure by analyzing a group of certified chronic arsenic posioning patients at a small mining village in Japan. When compared with expected number of desths, besed on sex-, age-specific mortality of Japanese in 1975, '80 and '85, all cancer, cancer of respiratory system and cancer of bladder, kidney and other and unspecified urinary organs showed a significant excess over the expected number. Divided by employment history, death due to all cancers, to respiratory cancer and to urinary tract cancer showed a significant excess among former workers of the mine. Classified into four cohorts by both employment history and smoking habit death from respiratory cancer showed a significant excess only in the cohort tespiratory cancer showed a significant exeess only in the cohort of former workers with smoking history, suggesting an interaction between exposure to arsenic and smoking. Eight sases among ten respiratory cancers and two urinary tract cancer cases were accompanied by cancer of other organs, including Bowen's disease.
Key words: Arsenic-Cancer-Epidemiology-Certified patients-The pollution health damage compensation law
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