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INDUSTRIAL HEALTH 1990,28,77-83
No Adverse Effects of Lead on Renal Function
in Lead-exposed Workers
Kazuyuki ONAE1), Haruhiko SAKURAI1), Toshiaki HIGASHI2),
Takashi MUTO1), Masaaki ICHIKAWA3)
and Norihiro SADAKI3)
1) Department of Preventive Medicine and Public Health, School of Medicine, Keio University
35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan
2) Department of Health Policy and Management, University of Occupational and Environmental Health
1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu City, Fukuoka 807, Japan
3) Japan Industrial Safety and Health Association, Occupational Health Research Center
5-35-1, Shiba, Minato-ku, Tokyo 108, Japan
(Received January 29, 1990 and in revised form March 26, 1990)
Abstract: A cross-sectional study was performed on 165 male lead-exposed workers to clarify the quantitative relationships between less sever exposure to lead and its effects on renal function in 1985. Mean and range of blood lead concentration (Pb-B) were 36.5mug/dl and 6-73mug/dl, respectively. Duration of lead expusure was 0.1 to 26.3 years. No lead-related changes were detected in serum creatinine concentration, beta-2 microgloburin in urine, creatinine clearance, beta-2 microgloburin clearance, and uric acid clearance. Twenty of the 165 workers had been exposed to lead for more than 10 years with mean duration of 21.0 years. Average concentrations of Pb-B in each individual during 1972 to 1984 were 26.1-66.6mug/dl. Renal function indices of these 20 workers were not different from those of remaining lead-exposed workers whose lead exposure duration were 10 years or less. These results suggest that long-term less sever exposure to lead up to 70mug/dl of Pb-B may not cause adverse effects on renal glomerular funciton and porximal tubular function.
Key words: Lead-Long-term exposure-Renal function-Cross-sectional study-Dose-effect relationship
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