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INDUSTRIAL HEALTH 1991,29,85-92
Allergologic Evaluation for Workers Exposed to
Toluene Diisocyanate
Jun HUANG1,2), Xiang-Pu WANG1), Atsushi UEDA2), kohji AOYAMA2),
Ben-Mei CHEN1), and Toshio MATSUSHITA2)
1) Laboratory of Environmental Medicine, Hunan Medical University, Changsha, China
2) Department of Hygiene, Faculty of Medicine, Kagoshima University, Sakuragaoka,
Kagoshima 890, Japan
(Recieved Feburuary 14, 1991 and in revised form April 3, 1991)
Abstract: A cross-sectional nivestigation for allergology was performed of 15 painters exposed to high concentrations of toluene diisocyanate (TDI)(0.07-0.17 ppm) during the process of handling polyurethane varnish in a furniture manufacturing facrtory. Asthmatic reactions such as dyspnea, wheezing related to workshifts and contact dermatitis were observed in four and three cases reapectively by questionnaire survey. Lung function tests on the painters showed significant decline in FEV1, %FEV1 and MMF compared to the referents. An increment in mast cell degranulation percentage could be seen in the painters. And also, patch testing with TDI were positive in five cases. From the results, it was suggested that both allergic pulmonary effects and contact sensitization had occured in TDI-exposed painters in this factory.
Key words: Toluene diisocyanate-Allergy-Asthma-Contact Dermatitis.
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